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Medical Treatments for Crohn's Disease

Evidence-based information on Crohn's disease treatments including biologics, steroids, surgery, antibiotics, and the latest medical research from the IBD community.

55 articles

A calm clinic exam room with an IV stand, an upholstered patient chair, and soft window light, the setting where biologic treatment decisions for Crohn's disease are made

Best Biologic for Crohn's Disease: How to Choose

There is no single best biologic for Crohn's disease. The right choice depends on disease severity, location, fistulas, prior treatments, safety, and your preferences.

A clinician's desk with two paper file folders side by side and a wooden anatomical model of the digestive system, comparing Crohn's disease and ulcerative colitis case notes

Crohn's Disease vs Ulcerative Colitis: Key Differences

Crohn's disease vs ulcerative colitis: Crohn's can affect any part of the GI tract through all bowel-wall layers, while UC affects only the colon's lining.

A clean pharmacy reference shelf with rows of unbranded medication boxes, two folded informational brochures, and a small upright IV bag, representing the full range of IBD medications for Crohn's disease and ulcerative colitis

IBD Medications Compared: Crohn's and Colitis Treatments

A complete, plain-English comparison of IBD medications for Crohn's disease and ulcerative colitis: drug classes, how they work, route, and what they treat.

Modern pharmacy display of recently approved IBD medications arranged in rows with informational brochures, representing the 2026 treatment landscape

New IBD Treatments in 2026: What Patients Should Know

New IBD treatments 2026: a plain-English, cited guide to recently approved Crohn's and colitis therapies, including IL-23 inhibitors, S1P modulators, and JAK drugs.

A single small oral tablet on a white ceramic plate beside a tall glass of water and a folded prescription pamphlet on a sunlit wooden kitchen counter, representing a once-daily Rinvoq routine

Rinvoq (Upadacitinib) for Crohn's Disease: A Patient Guide

Rinvoq (upadacitinib) is a once-daily oral JAK inhibitor for moderate-to-severe Crohn's disease. Learn how it works, the trial results, dosing, and safety risks.

Two unbranded biologic medication boxes side by side on a clean white pharmacy shelf with a folded informational leaflet, comparing Skyrizi and Stelara

Skyrizi vs Stelara for Crohn's Disease: A Patient Guide

Skyrizi vs Stelara for Crohn's disease: the SEQUENCE head-to-head trial found Skyrizi superior for endoscopic remission. Compare how they work, dosing, and safety.

An unbranded autoinjector pen and a folded informational pamphlet laid out on a clean counter in soft morning light, representing the at-home Stelara injection for Crohn's disease

Stelara (Ustekinumab) for Crohn's Disease: A Patient Guide

Stelara for Crohn's is an anti-IL-12/23 biologic given as a single weight-based IV infusion, then 90 mg under the skin every 8 weeks. Here is the evidence.

A bathroom door slightly ajar at the end of a softly lit hallway in warm morning light, representing the urgency and frequency that mark ulcerative colitis symptoms

Ulcerative Colitis Symptoms: A Complete Patient Guide

Ulcerative colitis symptoms include bloody diarrhea, urgency, rectal bleeding, and cramping. Learn how they vary by location, severity, and warning signs.

A modern hospital pharmacy counter with rows of unbranded medication boxes and an IV bag on a small stand, representing the range of ulcerative colitis treatment options

Ulcerative Colitis Treatment: A Patient Guide

Ulcerative colitis treatment uses 5-ASAs, steroids, immunomodulators, biologics, and small molecules to induce and maintain remission, with surgery as a cure.

Biosimilars for Crohn's disease showing comparison of originator and biosimilar biologic medications

Biosimilars for Crohn's Disease: A Patient's 2026 Guide

Biosimilars for Crohn's disease are reshaping IBD care in 2026. Learn how they work, what switching studies show, and how to talk to your GI team today.

Strictureplasty for Crohn's disease illustration showing bowel-sparing surgical technique

Strictureplasty for Crohn's Disease: Bowel-Sparing Surgery

Strictureplasty for Crohn's disease widens narrowed bowel without removing intestine. Learn the techniques, indications, recovery, and long-term outcomes.

Vedolizumab for Crohn's disease - gut-selective biologic therapy patient guide

Vedolizumab (Entyvio) for Crohn's Disease: A Patient Guide

Vedolizumab (Entyvio) is a gut-selective biologic for Crohn's disease. Learn how this anti-integrin therapy works, what trials show, and dosing options.

Hyperbaric oxygen therapy chamber used for Crohn's disease treatment

Hyperbaric Oxygen Therapy for Crohn's: A Patient Guide

Hyperbaric oxygen therapy may help heal perianal fistulas and reduce Crohn's disease inflammation. Learn how HBOT works, the evidence, and who benefits.

Illustration of small intestinal bacterial overgrowth in Crohn's disease showing bacteria in the small bowel

SIBO in Crohn's Disease: Symptoms, Diagnosis, and Treatment

SIBO affects up to 32% of Crohn's disease patients and is often mistaken for an IBD flare. Learn the symptoms, breath test diagnosis, and treatment options.

Illustration of C. diff infection risk factors in Crohn's disease patients

C. diff Infection in Crohn's Disease: A Patient Guide

C. diff infection hits Crohn's patients up to 10x more often. Learn how to tell a flare from infection, plus treatments like vancomycin, fidaxomicin, FMT.

Kidney stones and Crohn's disease - illustration of kidneys with oxalate crystals and inflamed intestine

Kidney Stones in Crohn's Disease: Causes and Prevention

Kidney stones affect Crohn's disease patients more often than the general population. Learn the main causes, risk factors, and proven prevention strategies.

Diagram illustrating bile acid diarrhea in Crohn's disease and the digestive system

Bile Acid Diarrhea in Crohn's: Causes and Treatment

Bile acid diarrhea affects more than 30% of Crohn's disease patients yet often goes undiagnosed. Learn the symptoms, SeHCAT testing, and treatment options.

Endoscopic balloon dilation procedure illustration for treating Crohn's disease intestinal strictures

Endoscopic Balloon Dilation for Crohn's Strictures Guide

Endoscopic balloon dilation for Crohn's strictures offers a minimally invasive alternative to surgery. Learn success rates, risks, and patient outcomes.

Vaccines for Crohn's disease patients illustrated with a syringe and protective shield

Vaccines for Crohn's Disease: What Patients Need to Know

Vaccines for Crohn's disease patients matter most before you start biologics. Learn which shots are safe, which ones to avoid, and how to time them right.

Postoperative Crohn's disease recurrence prevention roadmap with monitoring and treatment milestones

Preventing Postoperative Crohn's Recurrence: 2026 Guide

Up to half of Crohn's patients face endoscopic recurrence within a year of surgery. Learn 2026 evidence-based ways to prevent postoperative recurrence.

Capsule endoscopy pill camera next to a glass of water on a clinic table for Crohn's disease diagnosis

Capsule Endoscopy for Crohn's Disease: A Patient Guide

Capsule endoscopy for Crohn's disease uses a tiny swallowable camera to image the entire small bowel. Learn how PillCam works, what to expect, and the risks.

MR enterography scanner with a patient lying comfortably in a modern radiology suite

MR Enterography for Crohn's Disease: A Patient's Guide

MR enterography for Crohn's disease is a radiation-free scan that maps small bowel inflammation. Learn how MRE works, what to expect, and why it matters.

Diagram comparing top-down therapy for Crohn's disease versus step-up treatment strategy

Top-Down vs Step-Up Therapy for Crohn's: PROFILE Trial

PROFILE trial shows top-down therapy for Crohn's disease beats step-up: 79% sustained remission vs 15% at one year. What newly diagnosed patients need to know.

Subcutaneous infliximab self-injection pen for Crohn's disease maintenance therapy

Subcutaneous Infliximab (Zymfentra) for Crohn's Disease

Subcutaneous infliximab (Zymfentra) is the first FDA-approved self-injection biologic for Crohn's disease. Learn how it works, who it fits, trial data.

Therapeutic drug monitoring for Crohn's disease showing blood sample vial and biologic trough level results

Therapeutic Drug Monitoring for Crohn's: A Patient Guide

Therapeutic drug monitoring helps Crohn's disease patients on biologics like infliximab and adalimumab stay in remission. Learn how and when TDM is used.

Fecal calprotectin test for Crohn's disease with stool sample kit and lab results showing inflammation levels

Fecal Calprotectin Test for Crohn's: Levels and Normal Range

Learn what your fecal calprotectin number means in Crohn's disease, with 2025 ACG and AGA cutoff guidelines and tips for tracking flares without scopes.

Stem cell therapy for Crohn's disease showing mesenchymal and hematopoietic stem cell approaches

Stem Cell Therapy for Crohn's Disease: What Patients Should Know

Stem cell therapy shows promise for Crohn's disease, especially perianal fistulas. Learn about the latest research, types of treatment, and what to expect.

TL1A inhibitors for Crohn's disease representing a new drug class targeting inflammation and fibrosis

TL1A Inhibitors for Crohn's Disease: A New Drug Class

TL1A inhibitors are a promising new drug class targeting both inflammation and fibrosis in Crohn's disease. Explore the latest clinical trial results.

JAK inhibitors for Crohn's disease showing oral medication as an alternative to biologic infusions

JAK Inhibitors for Crohn's Disease: Real-World Results

JAK inhibitors offer a new oral treatment for Crohn's disease. Learn how upadacitinib (Rinvoq) works, real-world remission rates, and key side effects.

IL-23 inhibitors for Crohn's disease showing three FDA-approved biologic treatment options

IL-23 Inhibitors for Crohn's Disease: What Patients Should Know

Three IL-23 inhibitors are now FDA-approved for Crohn's disease. Learn how risankizumab, guselkumab, and mirikizumab work and what the latest trials show.

Portable ultrasound machine with transducer probe and gel bottle in a bright, modern clinic exam room

Intestinal Ultrasound for Crohn's Disease: A Guide to Non-Invasive Monitoring

Intestinal ultrasound is changing how Crohn's disease is monitored. Learn how this non-invasive, radiation-free tool works and how to access it.

Research lab desk with a computer monitor displaying an abstract 3D data visualization of a digital biological simulation, beside a stethoscope and clipboard.

Could a Digital Twin of Your Gut Help Predict Crohn’s Disease Flares?

Discover how digital twin technology is transforming Crohn’s disease care by simulating gut health, predicting flares, and personalizing treatments.

Vintage world map spread on a wooden desk with a compass, passports, magnifying glass, and small medicine vials placed across different regions.

Cultural Perspectives: Crohn’s Disease Diagnosis and Treatment Around the World

Explore cultural and regional differences in Crohn’s disease diagnosis and treatment around the world. Discover unique approaches to managing this chronic illness.

Lab bench with petri dishes of colorful bacterial cultures, a microscope, glass test tubes, and a notebook with hand-sketched diagrams.

The Role of Gut Microbiome Diversity in Crohn’s Disease Progression and Recovery

Discover how gut microbiome diversity impacts Crohn’s disease progression and recovery. Learn the latest research and practical tips to support gut health.

Long-Term Effects of Steroid Use in Crohn’s Disease Treatment

Long-Term Effects of Steroid Use in Crohn’s Disease Treatment

Learn the long-term effects of steroid use in Crohn's disease treatment, including bone density loss, and discover strategies to manage these risks effectively.

The Impact of Antibiotics on Crohn's Disease

The Impact of Antibiotics on Crohn's Disease

Discover the effects of antibiotics on Crohn’s disease, including risks of flare-ups and the influence on gut microbiota.

The Role of Anti-TNF Therapies in Crohn’s Disease

The Role of Anti-TNF Therapies in Crohn’s Disease

Learn how anti-TNF therapies work to manage Crohn’s disease by reducing inflammation, improving symptoms, and minimizing long-term damage, with a look at potential side effects.

Crohn’s Disease and Fertility: What You Need to Know

Crohn’s Disease and Fertility: What You Need to Know

Discover how Crohn's disease and its treatments impact fertility in both men and women, and learn tips for planning a family while managing the disease.

A clinician's desk from above with a coiled stethoscope, folded blood pressure cuff, a small heart-rate monitor, and an open medical journal with charts.

Crohn's Disease and Heart Health: Managing Cardiovascular Risks

Learn how Crohn’s disease can increase cardiovascular risks and discover strategies for managing heart health in Crohn’s patients.

The History of Crohn's Disease

History of Crohn's Disease: Who Discovered It and When

Crohn's disease is named after Dr. Burrill Crohn, who with Dr. Ginzburg and Dr. Oppenheimer first described it in a landmark 1932 paper. Explore its full history.

A breakfast tray with a glass of milk, leafy greens, vitamin D capsules, cheese, and dumbbells, representing bone-strengthening nutrition and exercise.

Crohn's Disease and Bone Health: Preventing Osteoporosis

Learn how Crohn’s disease can affect bone health and discover effective strategies for preventing osteoporosis in Crohn's patients.

A research lab setting with clear glass vials in a metal rack, a pipette on a tray, a centrifuge, and a folded lab coat in the background.

Exploring the Potential of Fecal Microbiota Transplant (FMT) for Crohn's Disease

Learn about the potential of Fecal Microbiota Transplant (FMT) in managing Crohn's disease, and how gut bacteria may help reduce inflammation and restore balance.

Understanding the Genetic Factors Behind Crohn’s Disease

Understanding the Genetic Factors Behind Crohn’s Disease

Discover how genetic factors contribute to the development of Crohn’s disease, including key genes linked to inflammation and immune response.

A calm hospital recovery room with a made bed in white linens, a side table with a water pitcher, folded blanket, and a small vase of white daisies.

The Role of Surgery in Crohn's Disease Management: When and Why It's Needed

Learn about the role of surgery in managing Crohn's disease, including when it's necessary, the types of surgeries available, and what patients can expect.

Understanding the Connection Between Crohn's Disease and Other Autoimmune Disorders

Understanding the Connection Between Crohn's Disease and Other Autoimmune Disorders

Explore the link between Crohn's disease and other autoimmune disorders, their shared risk factors, and implications for treatment.

A warm nursery scene with a wooden rocking chair, folded knit blanket, crib with a stuffed bear, cloud mobile, and tiny knitted baby booties.

Crohn's Disease and Pregnancy: A Comprehensive Management Guide

Learn how to manage Crohn's disease during pregnancy. Discover key strategies for before, during, and after pregnancy to ensure the health of both mother and baby.

Is the Integration of Gastroenterology and Endocrinology Clinics Changing the Game for IBD Patients?

Is the Integration of Gastroenterology and Endocrinology Clinics Changing the Game for IBD Patients?

Discover the new era of patient care with integrated gastroenterology and endocrinology for IBD. Learn how multidisciplinary clinics enhance outcomes.

Integrating Gastroenterology and Rheumatology in IBD Care

Integrating Gastroenterology and Rheumatology in IBD Care

Discover the vital role of integrating gastroenterology and rheumatology in IBD care. Learn how this holistic approach enhances patient outcomes.

Modern multidisciplinary clinic office with two chairs, medical charts, a stethoscope and an aloe plant

Maximizing Patient Outcomes: Integrating Gastroenterology and Dermatology for IBD Care

Discover the powerful impact of integrating gastroenterology and dermatology for IBD patients. Learn how collaboration leads to better care and outcomes.

Highlights from the 2024 Crohn’s & Colitis Congress

Highlights from the 2024 Crohn’s & Colitis Congress

Discover the groundbreaking advancements in IBD care at the 2024 Crohn’s & Colitis Congress. From innovative drug therapies to precision medicine, read the highlights now!

Noninvasive Monitoring: Tracking IBD with Sweat

Noninvasive Monitoring: Tracking IBD with Sweat

Discover the future of IBD management with noninvasive monitoring: Tracking IBD with Sweat. Learn how sweat analysis revolutionizes disease tracking.

Lab scene with biologic medication vials in a steel rack, a syringe on a sterile tray and nitrile gloves

Biological Treatments for Crohn's Disease: Past and Present

Explore the evolution of biological treatments for Crohn's disease, from Remicade to the latest advancements. Discover targeted and effective solutions.

Bathroom counter with bamboo toothbrush, natural toothpaste, floss and eucalyptus for oral hygiene

What's the Connection Between Gum Disease and IBD - Inflammatory Bowel Diseases?

Discover the surprising link between gum disease and IBD (Inflammatory Bowel Diseases). Uncover the complex connection and potential treatment approaches.

Discreet surgical consultation desk with medical folder, stethoscope and clipboard beside a glimpse of an operating room

The Uncomfortable Truth About Perianal Fistulas in Crohn's and Ulcerative colitis Patients

Uncover the truth about living with Perianal Fistulas in Crohn's and Colitis patients. From causes and symptoms to treatment options, find hope and support here.

Medical research desk with a vintage globe, stacked medical journals, reading glasses and a warm desk lamp

Unveiling the Hidden Epidemic: Crohn's Disease's Rising Global Impact

Crohn's disease rates are rising globally, affecting millions. Explore the epidemic's scope, regional patterns, and why this matters for patients worldwide.